A compound called rutin, commonly found in fruits and vegetables and sold over the counter as a dietary supplement, has been shown to inhibit the formation of blood clots in an animal model of thrombosis.These new findings, led by investigators at Harvard-affiliated Beth Israel Deaconess Medical Center (BIDMC) and published in Tuesday’s online issue of The Journal of Clinical Investigation (JCI), identify a novel strategy for preventing thrombosis, and help pave the way for clinical testing of this popular flavonoid as a therapy for the prevention and treatment of stroke and heart attack, as well as deep venous thrombosis (DVT) and pulmonary embolism.“It’s not always fully appreciated that the majority of Americans will die as the result of a blood clot in either their heart or their brain,” says senior author Robert Flaumenhaft, an investigator in the Division of Hemostasis and Thrombosis at BIDMC and associate professor of medicine at Harvard Medical School. “Approximately half of all morbidity and mortality in the United States can be attributed to heart attack or stroke.”The study focused on protein disulfide isomerase (PDI), which is found in all cells. Investigators in BIDMC’s Division of Hemostasis and Thrombosis had previously shown that PDI is rapidly secreted from both platelets and endothelial cells during thrombosis, when a clot forms in a blood vessel, and that inhibition of PDI could block thrombosis in a mouse model.“This was a transformative and unanticipated finding because it identified, for the first time, that PDI is secreted from cells in a live animal and is a potential target for preventing thrombosis,” says Flaumenhaft. However, because intracellular PDI is necessary for the proper synthesis of proteins, the scientists had to identify a specific compound that could block the thrombosis-causing extracellular PDI — without inhibiting the intracellular PDI.They began by conducting a high-throughput screen of a wide array of compounds to identify PDI inhibitors. Among the more than 5,000 compounds that were screened, quercetin-3-rutinoside (rutin) emerged as the most potent agent. “Rutin was essentially the champion compound,” says Flaumenhaft.A bioflavonoid that is naturally found in many fruits and vegetables, including onions, apples, and citrus fruits, as well as teas, rutin is also sold as an herbal supplement, having received a special designation for safety from the U.S. Food and Drug Administration (FDA). Surprisingly, studies of the rutin molecule demonstrated that the same part of the molecule that provides rutin with its ability to inhibit PDI also prevents the compound from entering cells.“That finding explained how this compound can be both a potent inhibitor of PDI and a safe food supplement,” says Flaumenhaft. “Our next questions were: Is this compound anti-thrombotic? Can it prevent blood clots?”The team went on to test rutin in a mouse model of thrombosis. Because they knew that humans would be taking rutin in pill form, they included studies in which the compound was administered orally and determined that it successfully retained its anti-thrombotic properties when it was metabolized following oral ingestion.“Rutin proved to be the most potently anti-thrombotic compound that we ever tested in this model,” says Flaumenhaft. Of particular note, rutin was shown to inhibit both platelet accumulation and fibrin generation during thrombus formation. “Clots occur in both arteries and in veins,” explains Flaumenhaft. “Clots in arteries are platelet-rich, while those in veins are fibrin-rich. This discovery suggests that a single agent can treat and prevent both types of clots.”Even with the use of existing anti-clotting therapies, such as aspirin, clopidogrel (Plavix), and warfarin (Coumadin), each year there are approximately 400,000 recurrent episodes among patients who previously experienced a stroke or heart attack, says Flaumenhaft.“A safe and inexpensive drug that could reduce recurrent clots could help save thousands of lives,” he adds. “These preclinical trials provide proof-of-principle that PDI is an important therapeutic target for anti-thrombotic therapy, and because the FDA has already established that rutin is safe, we are poised to expeditiously test this idea in a clinical trial, without the time and expense required to establish the safety of a new drug.”
Star Files Related Shows from $149.00 Lin-Manuel Miranda ‘The Hamilton Mixtape’ View Comments Here’s your chance to get into the room where it happens! After the original Broadway cast recording of Hamilton garnered a Grammy and went double platinum, the eagerly anticipated The Hamilton Mixtape is set to drop on December 2. Boasting vocals from music industry greats like Busta Rhymes, Alicia Keys and more, check out below’s December 1 preview party at the Richard Rodgers Theatre. We have a feeling that you’ll be most satisfied. Hamilton
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Today marks 60 days since the launch of The Lost Art of Closing: Winning the 10 Commitments That Drive Sales. The feedback you receive about a book is always interesting. Here are a few important takeaways.I included a model of the language that you can use at the end of each chapter so that the reader could develop something that would work for them. You know, their words, something that fits them. Readers are emailing to share with me that they are using the sample language very similar to how it is laid out in the book, and they are surprised how well it works.My view on this is that there are a lot of things that work, and plenty more that don’t. It’s the fact that they know what commitment they need and have some idea as to how to ask for it that is bringing them success.One sales leader told me that he is using the commitments to coach his sales team, and asking them what commitment they intend to gain during the next client interaction. Invariably, they start with the Commitment to Decide, the final ask. But as they talk through their plan with him, they discover that they really need the Commitment to Collaborate or the Commitment to Build Consensus or some other earlier commitment.It’s another proof point that the very idea of “closing” has been limited to the final ask for so long that it persists. It’s also proof of the central premise I had when I pitched the book: No one has ever written down the commitments that tend to come between target and close, what Neil Rackham called an “advance” in SPIN Selling. These commitments are what allow you to control the process and help your clients with better results.On the negative side, there are still people who are put off by the word “closing.” They believe that the book contains 110 closes with tie downs and smarmy language that is going to make them feel bad about themselves and ruin the trust they are trying to build with their clients. There are not any “closes” in the book that resemble anything you have ever seen in a book on closing. Instead, there are strategies for asking for commitments that build trust and allow you to better serve your clients.If you haven’t yet picked up The Lost Art of Closing, please do check it out. I know it will help you produce better results now and in the future. Send your receipt to me at [email protected], and I will send you the workbook and an invite to the Facebook Mastermind Coaching group. At the time you are reading this, there will be five weeks of videos archived for you in the videos section. Essential Reading! Get my 3rd book: Eat Their Lunch “The first ever playbook for B2B salespeople on how to win clients and customers who are already being serviced by your competition.” Buy Now
The Ministry of Industry, Investment and Commerce and the United States Chamber of Commerce are to host a joint conference in Jamaica, aimed at promoting the Global Logistics Hub Initiative.This was disclosed by the Minister of Industry, Investment and Commerce, Hon. Anthony Hylton, during a meeting with Ambassador to the United States, His Excellency Stephen Vasciannie at the Embassy in Washington, D.C., last week.Mr. Hylton said the decision to hold the conference was made during a meeting with representatives of the US Chamber of Commerce, who pledged their support to partner with Jamaica on this project.He added that the Chamber will be taking a large delegation of members and investors to the conference, to discuss how they can participate in the various investment opportunities that can benefit both countries.The Minister said that meetings with representatives of the World Bank, the Inter-American Development Bank (IDB) and the US Trade and Development Agency (USTDA), were very fruitful. Representatives from each organization expressed their willingness to work alongside Jamaica for a successful project.Mr. Hylton said what was significant about the trip to Washington was the vast number of requests for unscheduled meetings from potential investors who are interested in the logistics hub. The Minister and a delegation were in Washington to promote the Global Logistics Hub Initiative, which is aimed at taking advantage of the expansion of the Panama Canal by 2015.Mr. Hylton was accompanied by Executive Director of the American Chamber of Commerce of Jamaica (AMCHAM), Becky Stockhousen; Vice President of Planning and Corporate Development at Jamaica Promotions Corporation (JAMPRO), Dr. Dana Morris-Dixon; President of the Jamaica Chamber of Commerce, Francis Kennedy; Chairman of the Logistics Taskforce, Eric Deans and Advisor to the Minister, Reginald Nugent.
By Meagan FiddlerAPTN National NewsRED LAKE, Ont.-Stanley Fiddler says he was taken on a starlight tour by an OPP officer who picked him up on Oct. 29, drove down a highway, opened the door to the cruiser and dropped him off several kilometres from Red Lake, Ont.The officer has since been suspended by the OPP which is conducting an internal investigation of the incident.“He didn’t say nothing, just drove off down Hwy 35,” said Fiddler, in an interview with APTN National News. “He just opened the door and that is all.”Fiddler, from Sandy Lake First Nation, is an alcoholic who lives on the streets in this town about 300 kilometres north of Kenora, Ont.Venessa Keesick saw Fiddler walking down the highway that night, making his way back to town. She asked Fiddler what happened and then filed a complaint with the OPP.“(Fiddler) told me he had been drinking. He got picked up. He thought he was going to jail to sleep it off, but no, they turned down the highway and kept going and going,” said Keesick, in an interview. “He did say that he did distinguish the officer because he had an accent.”The complaint seems to be substantiated by the officer’s suspension.“The OPP is conducting an internal investigation into the release of a person in custody bya member of the Red Lake OPP detachment,” said a statement from the OPP. “A member of the Red Lake OPP detachment has been suspended from durty.”Keesick said she wasn’t surprised by Fiddler’s story of a starlight tour.“It’s happened before, but years ago to my friend and I’ve heard it happen before, but it’s pretty close to home because I used to work with the guy,” she said.Keesick got to know Fiddler at Red Lake’s emergency shelter.Sandy Middleton, the manager at the shelter, said he’s heard the same thing.“I’ve heard of it happening before, but it’s substantiated,” said Middleton.Middleton’s work with the homeless at the shelter gives him a good perspective of their daily struggles. He hopes this isn’t one more hardship added to Fiddler’s already full plate.“I think, if it did happen, it shouldn’t. These are people that really don’t have the acumen to look after themselves that you or i may. They depend on others to do that for them,” he said.Keesick says that’s why she filed the complaint, because she knew Fiddler wouldn’t.“Most of these people don’t have a voice. They keep quiet about bad things that happen,” she [email protected]
Facebook Twitter Google+LinkedInPinterestWhatsApp#TurksandCaicos, November 9, 2017 – Providenciales – The Turks and Caicos Government is pleased to welcome its team of new Starters.“Following on from a successful recruitment exercise during the last quarter, we are pleased to welcome our new front line officers within the Road Safety, Fire, Environment and Coastal Resources, Environmental Health, Maritime and Employment Services Department,” stated Deputy Governor, Her Excellency, Anya Williams.“We welcome each and every one of you to the Turks and Caicos Civil Service and hope that you will find your time with us to be a most engaging and productive one. I encourage you to be professional and devoted to your duties and to strive to be the best employee that you can be. We look forward to working with you and towards you helping us to build and to continue to improve the civil service.”New Recruits:Conservation OfficersDewandre Smith – GDTCurtis Been – PLSDewandre Smith Fire Officers – PLSRicardo ForbesRoosevelt GlintonRicardo Forbes & Roosevelt Glinton Ministry of Border Control – PLSShequida Williams – Customer Service ClerkPrenell Dean – Labour InspectorIngrid Simons – Case WorkerShequida WilliamsPrenell DeanIngrid Simons Related Items: Maritime DepartmentYasmah Adams-Richards – Administrative OfficerPress Release: TCIG Facebook Twitter Google+LinkedInPinterestWhatsApp Liaison Officers – PLSAshley JenningsAlisa FolkesAlisa FolkesAshley Jennings Environmental Health Officer – PLSTashy ForbesTashy Forbes
San Diego rockers “Switchfoot” touring Europe with Bon Jovi this summer June 11, 2019 SAN DIEGO (KUSI) – This summer, local San Diego band “Switchfoot” will be going on tour in Europe with artist Bon Jovi.Switchfoot performed a cover of Bon Jovi’s famous “Living on a Prayer” – https://www.youtube.com/watch?v=s91WsxlOUXA Categories: Local San Diego News FacebookTwitter Posted: June 11, 2019 KUSI Newsroom, KUSI Newsroom Updated: 11:31 PM