Dwayne Hawk seeks Holbrook council seat

first_imgFebruary 27, 2019      (Hawk is one of two candidates seeking the two-year term on the Holbrook City Council on the March 12 election.)       I am the art teacher at Holbrook High School. I have called HolbrookSubscribe or log in to read the rest of this content. Bottom Ad Dwayne Hawk seeks Holbrook council seatcenter_img Dwayne Hawklast_img

Rajasthan Congress MLA says rape case on cops false BJP corners Ashok

first_img Explained: What is Rajasthan’s free medicine scheme By Express News Service |Jaipur | Published: July 16, 2019 2:15:28 am Advertising Related News The woman’s brother-in-law was arrested for theft and died in police custody on July 6. The woman has alleged that she was kept in illegal detention for several days, and was later gangraped by policemen.Sharma said in the Assembly that he was not advocating any side, but that the allegations of rape are wrong. “The allegations of rape and that of nails being plucked are false. A history-sheeter and blackmailer who wanted to settle scores with local police incited the family into lodging the FIR,” he told The Indian Express.Opposition BJP demanded a CBI probe and questioned the delay in lodging FIR. Leader of Opposition Gulab Chand Kataria said there was a long delay in lodging the FIR, which showed that the victim and her family were not heard by the administration. Rajasthan constable beaten to death; CM Ashok Gehlot orders probe Gehlot: Will bring law against mob lynching, honour killing gangrape, Rajasthan police, Rajasthan gangrape, Rajasthan Dalit woman gangrape Rajasthan, Dalit gangrape, Rajatsthan dalit rape case, Indian express news Rajasthan CM Ashok Gehlot. (File photo)A day after an FIR was lodged against several police personnel in Rajasthan’s Churu district for the alleged gangrape of a Dalit woman, Congress MLA from Sardarsahar, Bhanwarlal Sharma, on Monday claimed that the allegation is false. Post Comment(s)last_img read more

Project Second Innings In Dahod new chapter for retired teachers — and

first_imgWritten by Aishwarya Mohanty | Vadodara | Published: July 15, 2019 12:43:42 am Post Comment(s) Until last year, all that 59-year-old retired teacher Lakshman Chauhan wanted to do was spend time at his “small farm” near his home in Vadela. Today, he is back in front of the blackboard at the school, happy to be conducting remedial sessions for students in need.What has brought Bhabhor and Chauhan together is Project Second Innings, launched by the Dahod administration under the NITI Aayog’s Transformation of Aspirational Districts programme. Dahod is among 117 districts identified by NITI Aayog, with education as one of the core areas of focus.The project was launched in 2018 to help improve learning outcomes in primary and upper primary classes, specifically in reading, writing and Maths. And Chauhan is among 517 retired teachers who have voluntarily signed up, so far.“I still believe in the traditional system — read, write, practise and learn. If they can learn the language well, they can read and understand other subjects, too. I continuously conduct dictations and sessions where students read out from their textbooks,” says Chauhan. Best Of Express NRC deadline approaching, families stranded in Assam floods stay home In undecided Congress, first open call for Priyanka: She should be party chief Advertising Top News education, education poverty, indias poor education, dahod, dahod niti aayog, niti aayog education projects Retired teacher Natha Barjod at the primary school in Kalia Valunda village, Dahod. (Express Photo by Bhupendra Rana)UNTIL LAST year, Surya Bhabhor had the odds stacked against him. His parents were away, working as migrant workers, and he was with his grandmother in Gujarat’s Dahod, struggling to cope at school, finding it “difficult to read and write English”. Today, the 11-year-old breezes through the alphabet, and is happy to write his name in English and read out from a Class 5 textbook at the primary school in Vadela village.center_img Karnataka: SC to rule today, says Speaker’s powers need relook Advertising In undecided Congress, first open call for Priyanka: She should be party chief Then, there’s 78-year-old Natha Barjod, the “Master ji” at the primary school in Kalia Valunda village. “I retired as a school principal in 1999, and was approached by the district last year to volunteer as a tutor in my village. I get about Rs 20,000 in pension, and both my sons are working, so I don’t have anything else to worry about. I help the students here with Gujarati and Maths,” he says.The results are showing. At last year’s Gunotsav, an annual evaluation in government primary schools, 58,639 students from classes 6 to 8 in Dahod were graded below 5 on a scale of 1-10 in reading, 66,133 in writing and 67,666 in Maths. Of these students, 27,598 improved their grades this year to above 6 in reading, 28,664 in writing and 32,827 in Maths.Dahod has also climbed one rung from the bottom among 33 districts in the Secondary School Certificate (SSC ) results — from last in pass percentage (37.35%) in 2018 to one step higher (49.18%) this year.According to District Collector, Vijay Kharadi, 285 more retired teachers are being drafted, with a target of 1,000 by the year-end. “We are also looking at retired government officials based in their villages who can devote time for the project,” he says.Nodal Education Officer (Aspirational District), Janak Patel, says they pick volunteers from an updated database. “As soon as teachers retire, we approach them to teach in their own villages. If they agree, we organise classes for an hour before or after normal school hours,” says Patel. NRC deadline approaching, families stranded in Assam floods stay home District Development Officer, R K Patel, says migration is “one of the key” factors that has led to lower learning outcomes in Dahod, a tribal district. Labour records show that over 30,000 people migrate every year on an average in search of work, mostly from February to July. Of them, about 15,000 return during the monsoon but leave again by August-end.“We realised that once students go home, they don’t get help because their parents are mostly out for work. With the experience and expertise of retired teachers, they get extra attention in school itself,” he says.Vinod Rao, Secretary, Education Department, Gujarat, says the “major challenge” in the district is attendance. “Against the state performance of 57% students with attendance above 80%, Dahod has only 17%. All these initiatives are directed towards reviving attendance,” he says. Karnataka: SC to rule today, says Speaker’s powers need relook last_img read more

DNA Printing in the Cloud Part 1

first_imgNed Madden is a California-based marketing professional and journalist who writes about technology and business-related topics. You can email him at nedmadden[at]cox[dot]net. Genome – ‘Book of Life’ In the DNA printing process, plant and animal genomes are sequenced in computerized sequencers using gel electrophoresis technology, translated from genetic code into computer code, uploaded to cloud databases (Internet of DNA) for storage and analysis, then designed in silico using CAD software.Laboratories then download digital “gene of interest” DNA segments for chemical assembly of an artificial DNA strand that is fused with a bacterial plasmid (a replicating non-chromosomal DNA segment) to become an rDNA molecule cloning and expression vector (carrying agent).The rDNA is inserted into a host E. coli bacterium that reproduces exponentially through binary fission to amplify the original downloaded genetic fragment as individual DNA clones in a colony capable of production of large quantities of the original target gene to manufacture “protein of interest” products encoded by that gene.DNA printing is based on the natural flow of genetic information in a cell from DNA through RNA to amino acids to proteins, from gene to protein, genome to proteome, genomics to proteomics. DNA, life’s foundation blueprint, makes up genes, the instructions for making proteins — the complex molecules that do most of the work in living organisms.”DNA makes RNA makes proteins make Life.”That simple formula, which has worked well for life on Earth for at least half a billion years, very recently has turned into a trillion-dollar modern global industry based on an updated formula: “People make DNA.”DNA, or deoxyribonucleic acid, is the macromolecule that is the main component of the gene-carrying chromosomes in every cell nucleus — the enzymatic substance that contains the genetic instruction guide for the development and functioning of all living things. It determines inheritance, codes for proteins, and makes up the enigmatic core around which our behavior, desires, fears and health, to a large extent, revolve.”The greatest single achievement of nature to date was surely the invention of the molecule DNA,” wrote the late scientist and author Lewis Thomas in his book The Lives of a Cell. “All of today’s DNA, strung through all the cells of the Earth, is simply an extension and elaboration of the first molecule.”Grand as it may be, DNA is basically an organic chemical molecule made from atoms of carbon, hydrogen, nitrogen, oxygen and phosphorous. Yet from such commonplace ingredients arise the essential building blocks of our physical identity.DNA has enabled us to manipulate its very substance in order to create forms of life Nature never conceived. This profound development is due to rDNA technology and recombinant protein production in the DNA printing process. Genomes are the full sets of chromosomes within cells containing all of an organism’s genes and DNA (while a proteome is the full complement of proteins that occur within a cell, tissue or entire organism).The human genome is our “book of life.” In each cell there are 3 billion base pairs, the “letters” of DNA that spell out the recipe of a person. The human genome is the complete set of nucleic acid (DNA/RNA) sequences for humans, encoded within the 23 chromosome pairs in cell nuclei (and in a small DNA molecule found within individual mitochondria outside the cell nucleus).The human genome contains around 20,000 genes, the stretches of DNA that encode proteins. A coding gene consists of enough DNA to code for one protein, but these genes account for only about 1.2 percent of the total genome, called the “exome.” The other 98.8 percent consists of what’s known as “noncoding” DNA molecules.Non-protein genomic coding regions not related directly to making proteins once were referred to as “junk” DNA. Now they are thought of more as a completely dense jungle of mysterious stuff. The ENCODE group, a project of the U.S. National Human Genome Research Institute (NHGRI), produced a stunning inventory of previously hidden switches, signals and signposts embedded like runes throughout the entire length of human DNA.Here’s where the genome fits into living biological systems:Organism > tissue > cells > cell nucleus > genome > chromosomes > genes > DNA/RNA > nucleotides (DNA’s fundamental building blocks) > nucleobase pairs (A-T/C-G). (Note: Mitochondria — energy generators outside cell nuclei — have their own DNA and are another topic.)Nucleotides are the backbone sides of DNA’s double-helix spiral ladder, and these sides are linked together by four different types of paired chemical ladder “steps”: adenine-thymine and cytosine-guanine (also in reverse order — T/A-G/C).The first full DNA genome to be mapped and sequenced was that of bacteriophage phiX174 in 1977. The first plant genome to be sequenced was Arabidopsis thaliana, a wild member of the mustard family, in 2000. The Human Genome Project (HGP), which involved sequencing of the 3 billion base pairs that make up the human genome, was completed in April 2003.Sequencing led to synthesis, and in 2010, American biotechnologist, biochemist, geneticist and businessman J. Craig Venter, along with colleagues from The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute (JCVI), were the first to transfect a cell with a synthetic chromosome, using entirely synthesized DNA to create a self-replicating microbe, dubbed Mycoplasma laboratorium. ‘DNA Printing’ in the Cloud, Part 2 The concept of DNA printing borrows from 3D printing, an additive manufacturing process using computer control to create three-dimensional objects of all kinds (e.g., tools, toys, jewelry, sculptures). Today, there are even 3D-printed firearms. The 5,300-year-old frozen European mummy Ötzi the Iceman has been rendered as a 3D-printed plastic and resin model.DNA printing is a 3D additive process, because each chromosome consists of two very large molecules of DNA wound around each other (each strand is a separate molecule).The artificial DNA manufacturing process is “additive” because DNA printing specifically involves using automated laboratory workstations to synthesize (create and build), assemble, and churn out tailored stretches of artificial DNA.Can DNA be “printed”? Yes and no.In sequencing DNA, DNA’s four physical chemical nucleobases — adenine, thymine, cytosine and guanine — can be represented as the letters A, T, C and G for the purposes of translating their sequential order in genes and the genome. These letters can be stored in computer memory, communicated in electronic form, and even printed out as text if necessary.In synthesizing (building up) DNA into an artificial gene, that gene is assembled as chemicals on a physical structure and then cloned (copied) — not “printed” in the sense of producing written materials.The resulting genetic materials are used to develop products and investigate technical issues across many life science fields, such as cancer immunotherapy, neuroscience, virology and vaccine design, therapeutic antibody engineering, plant biology research, biochemistry, genome analysis and manipulation, and more.Much of the momentum stems from recent advances in once arcane but now increasingly mainstream state-of-the-art techniques and technologies in areas like genetic engineering, industrial biotechnology, synthetic biology, computational biology, biological computing, in silico predictive modelling, cybergenomics and bioinformatics.The Internet of DNA — a global network of databases connected in the cloud on a peer-to-peer communications model — consists of a worldwide array of data centers full of servers containing centillions of bytes of animal, plant and microbial genomic information. New Formula Recombinant DNA and Proteins rDNA entails the way in which genetic material from one organism artificially is introduced into the genome of another organism, and then replicated and expressed by that other organism. Genes inserted into foreign host organisms produce new genetic combinations that are of value to science, medicine, agriculture and numerous (if not all) other fields.In the time since the mapping of the human genome was completed in 2003, DNA printing, rDNA technology and recombinant protein production have become a monster business worldwide. Genes make the proteins that make life, but mankind uses both genes and the proteins it creates to make money.The global rDNA technology market size, estimated at US$497.7 billion in 2016, is expected to reach $844.6 billion by 2025 (and probably much more, much sooner), according reports Grand View Research released last year.rDNA is possible because DNA molecules from all organisms share the same chemical structure, and differ only in the nucleotide sequences within that identical overall structure. Proteins that can result from rDNA expression within living cells are termed “recombinant proteins.”A recombinant protein is an organic molecule that has been encoded by a cloned rDNA gene. Recombinant protein results from a manipulated form of protein generated in various ways to produce large quantities of special proteins, modify gene sequences, and manufacture useful commercial products such as enzymes, growth factors, hormones, antibodies, vaccines and much more.The global recombinant protein market was valued at $347.2 million in 2016 and is expected to surpass $593.4 million by 2025 globally, according to Coherent Market Insights.Many “biologics” — medicines or drugs made of large, complex mixtures of molecules from living organisms and including tissues, genes, allergens, blood components and more — result from recombinant protein applications and work by targeting particular chemicals or cells involved in the body’s immune system response. Biologics require FDA approval for commercial use.Some of the more well known rDNA-derived biologics are used to treat rheumatoid arthritis and other autoimmune ailments like psoriasis and Crohn’s disease. These biologics include Humira (adalimumab), Remicade (infliximab), Rituxan (rituximab) and Enbrel (etanercept). TV commercials promoting these products have been airing incessantly of late, targeting an aging, often ill, population.The biologics market was valued at $254.9 billion in 2017 and projected it to reach $580.5 billion by 2026 in a Research and Markets report published this spring.The numbers mentioned above no doubt overlap, but the cash certainly flows in the hundreds of billions of dollars range because rDNA technology and recombinant protein composition have led to a wealth of exotic new products from entire new industries pouring out of clinical, R&D and production laboratories into the global marketplace.None of it would be possible without sequencing of the human genome, which made DNA printing possible. The shape of the Genome poemis scattered stars; a twinkling netof orchestrated switchesMolecules drafted through millennia,coagulating endless dreams of water;Chemistry’s infinite creative palettesampling light and elementsdandelion suns, beheaded as aristocrats,lion-shorn — still imagine symbiotic airlifting their lost materials,on round, star-hair wings.– “The Human Genome: Poems on the Book of Life” by Gillian K. FergusonVaccines grown in heads of lettuce … auto and aircraft tire rubber made from dandelion taproot sap … designer pharmaceutical “biologics” to fight autoimmune diseases like MS, diabetes … neoteric industrial enzymes, artificial XNA polymers, anaerobic digestion biofuels … . In their journey from DNA to protein, each of these noteworthy products shared something in common: They were the result of the use of recombinant DNA (rDNA) molecules in a process called “DNA printing” — aka “artificial gene sequencing, synthesis and protein production.”Each product began as a digital “gene of interest” in a genomic database on the cloud-based Internet of DNA, represented in computer program code specifying the precise order of four chemical building blocks — the “nucleobases” A,T, C and G ([A]denine, [T]hymine, [C]ytosine and [G]uanine) — along a segment of DNA that would be used to turn that sequential computer code into actual genetic material.Each ended up as a “protein of interest” organic molecule in a laboratory machine called a “synthesizer,” developed for use in protein production, drug discovery, clinical diagnostics and the manufacture of useful commercial products. 3D Printinglast_img read more

Skintoskin contact may promote attachment between parents and preterm infants

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 19 2018For premature infants in the neonatal intensive care unit (NICU), skin-to-skin contact with parents influences levels of hormones related to mother-infant attachment (oxytocin) and stress (cortisol) – and may increase parents’ level of engagement with their infants, reports a study in Advances in Neonatal Care, official journal of the National Association of Neonatal Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.Promoting early contact and parental engagement might help to lessen the risk of neurodevelopmental delay associated with preterm birth and NICU care, according to the exploratory study by Dorothy J. Vittner, PhD, RN, CHPE, of University of Connecticut School of Nursing and colleagues. They write, “Parental touch, especially during skin-to-skin contact (SSC) has potential to reduce adverse consequences.”Study Attempts to Measure Benefits of Skin-to-Skin Contact for Preterm InfantsThe pilot study included 28 preterm infants, average gestational age 33 weeks. All infants were in stable condition while receiving NICU care. Infants underwent periods of SSC on two consecutive days: once with the mother and once with the father. Saliva samples were collected from infants and parents to measure levels of oxytocin, a hormone that has been linked to maternal-infant attachment; and the stress-related hormone cortisol.”Oxytocin facilitates social sensitivity and attunement necessary for developing relationships and nurturance for emotional and physical health,” the researchers write. Cortisol plays an important role in the “fight or flight” reaction to fear or stress.Levels of both hormones changed in response to SSC. “Oxytocin significantly increased and cortisol levels decreased for mothers, fathers, and infants during SSC as compared to baseline,” Dr. Vittner and coauthors write. The changes indicate the “calming and beneficial impact of SSC for both parents and infants.”Parents also completed a questionnaire called the “PREEMI” (Parent Risk Evaluation and Engagement Model and Instrument) scale, designed to measure attachment between parents and their preterm infants. Overall PREEMI scores indicated a “moderate to high” level of parental engagement for all participants.Related StoriesLoose double-stranded RNA molecules spur skin rejuvenationScientists discover how resistance to the chemotherapy drug 5-fluorouracil arisesCannabis ingredient shows promise as potential antibiotic for superbugsIncreased oxytocin and decreased cortisol levels during SSC were associated with higher PREEMI scores by the time the infant was discharged from the hospital. “We believe these findings suggest that parents with a lower salivary cortisol as seen with SSC (decreased stress) may facilitate increased parental engagement,” Dr. Vittner and colleagues write.Mothers and fathers had similar increases in oxytocin during SSC. In mothers, the rise in oxytocin was related to increased parental engagement. Unexpectedly, however, increased oxytocin during SSC in fathers was negatively related to parental engagement. Dr. Vittner and colleagues note that for many fathers, the study SSC intervention was the first time they had held their infants.The study provides new evidence of how SSC might work to promote attachment between parents and premature infants. “The changes in oxytocin and cortisol levels provide robust support to advocate for increased SSC during infancy, especially for the vulnerable infant in the NICU,” the researchers write. They note that further studies will be needed to understand these relationships, and how they affect parent-infant relationships – especially in overcoming the obstacles posed by having a premature infant who need NICU care.The results also suggest that the PREEMI questionnaire can provide a “window into parent engagement,” potentially useful in identifying parents who may need interventions to increase engagement with their premature infant. Dr. Vittner and coauthors conclude: “Uncovering the bio-behavioral basis of early parent-infant interactions is an important step in developing therapeutic modalities to improve infant health outcomes.”​ Source:http://home.lww.com/news.entry.html/2018/10/18/for_preterm_infants-h9Ao.htmllast_img read more

Novel therapeutic targets based on biology of aging show promise for Alzheimers

first_img Source:https://www.alzdiscovery.org/ Reviewed by James Ives, M.Psych. (Editor)Dec 10 2018A scientific strategy that explores therapeutic targets based on the biology of aging is gaining ground as an effective approach to prevent and treat Alzheimer’s disease, according to research published in the December 7, 2018 online issue of Neurology®.A comprehensive review of the clinical trial landscape, including current agents being studied for the prevention and treatment of Alzheimer’s disease (and other dementias), points to the need to develop and test drugs based on an understanding of the multiple effects of aging on the brain.”Alzheimer’s is a complex disease with many different factors that contribute to its onset and progression,” says Dr. Howard Fillit, founding executive director and chief science officer of the Alzheimer’s Drug Discovery Foundation (ADDF), senior author of the review paper. “Decades of research have revealed common processes that are relevant to understanding why the aging brain is vulnerable to Alzheimer’s disease. New therapeutics for Alzheimer’s disease will come from this understanding of the effects of aging on the brain.”The only approved medications for Alzheimer’s disease relieve some symptoms but do not halt disease progression. New therapies that prevent, slow, or stop the disease are urgently needed to fight the growing Alzheimer’s disease burden in the United States and around the world. And, aging biology provides numerous novel targets for new drug development for Alzheimer’s disease, notes Dr. Fillit.”Our success in fighting Alzheimer’s disease will likely come from combination therapy – finding drugs that have positive effects on the malfunctions that happen as people age,” says Dr. Fillit. “Combination therapies are the standard of care for other major diseases of aging, such as heart disease, cancer, and hypertension, and will likely be necessary in treating Alzheimer’s disease and other dementias.”Increasing age is the leading risk factor for Alzheimer’s disease, a progressive neurodegenerative disease that affects 5 million people in the United States and about 50 million globally. With a growing aging population, the Centers for Disease Control and Prevention projects the burden of Alzheimer’s disease will nearly triple to 14 million people by 2060.Related StoriesHealthy lifestyle lowers dementia risk despite genetic predispositionSleep decline in one’s 50s, 60s increases risk of Alzheimer’s diseaseSex plays major role in Alzheimer’s disease riskWith aging, many biological processes go awry that have also been implicated in Alzheimer’s disease. For example, as people age, they are more likely to have chronic systemic inflammation and neuroinflammation, which is associated with poorer cognitive function. Other aging malfunctions include impaired clearance of toxic misfolded proteins, mitochondrial and metabolic dysfunctions (associated with diabetes), vascular problems, epigenetic changes (changes in gene regulation without alterations in the DNA sequence), and loss of synapses (points of communication between neurons).Later-phase (phase 3) trials are dominated by drugs targeting beta-amyloid and tau, the classic pathological hallmarks of Alzheimer’s disease (of phase 3 trials, 52% are targeting amyloid or tau), but other strategies are gaining ground and are in phase 1 or 2 trials, according to the review paper.Although therapeutic attempts to remove or decrease the production of beta-amyloid have been largely unsuccessful in altering the disease course of Alzheimer’s disease, says Dr. Fillit, researchers learned important information from those clinical trials even if they didn’t immediately result in treatments for Alzheimer’s patients. And recent clinical trials suggest that problems with clearance of beta-amyloid may yet prove fruitful.”It is currently not known if these classic pathologies (amyloid and tau) represent valid drug targets and if these targets alone are sufficient to treat Alzheimer’s disease,” says Dr. Fillit. “Targeting the common biological processes of aging may be an effective approach to developing therapies to prevent or delay age-related diseases, such as Alzheimer’s.”last_img read more

Scientists find link between colitis and colon cancer

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 14 2019Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer.Inflammation is supposed to be a short-term response to an infection or other irritant in the body that is essential to eliminating it. But when inflammation persists, it can contribute to a myriad of common conditions, from cancer to cardiovascular disease.In their quest to determine just how chronic inflammation of our large intestines, or colon, enables cancer, a scientific team led by Dr. Kebin Liu at the Medical College of Georgia and Georgia Cancer Center at Augusta University has found it turns one more protective mechanism against us and silences another.The pathway to cancer they delineated in the journal Cell Reports goes like this: The chronic inflammation of ulcerative colitis prompts high levels of myeloid-derived suppressor cells, or MDSCs, to accumulate in the colon. High levels of MDSCs, in turn, produce higher levels of IL-10, a cytokine known to suppress inflammation. But at this high level, the function of IL-10, like the environment in the colon, changes. IL-10 instead activates STAT3, a protein that works as a gene regulator, which in turn increases expression of two genes – DNMT1 and DNMT3b – in the colon. These genes alter the DNA of and ultimately silence a tumor suppressor called interferon regulator factor 8, or IRF8.Liu notes that the pathway they found that ends with silencing IRF8, likely is not a factor for non-colitis associated colon cancer.Next steps include finding ways to inhibit high expression of IL-10 in the colon.”IL-10 has a dual function. It can either be promoting or interfering with an immune response,” says Liu. “What we found here is IL-10 promotes colon cancer.”In a healthy state, IL-10 and IRF8 have no known interaction but both work in different ways to protect against invaders, says Liu, a cancer immunologist in the MCG Department of Biochemistry and Molecular Biology.The scientists set out to look at whether and how the two are connected in a chronically inflamed colon and test the hypothesis that IRF8 functions as a colorectal cancer suppressor.They created a mouse missing IRF8 in the epithelial cells that line the colon and found plenty of evidence to support their hypothesis. The mice were much more susceptible to chronic inflammation, had less normal cell death in this high-cell turnover area and got more tumors. They also found that in the face of chronic inflammation, IRF8 is silenced, and that in human cancer, IRF8 is downregulated compared to normal colon tissues.Related StoriesBacteria in the birth canal linked to lower risk of ovarian cancerNew protein target for deadly ovarian cancerSugary drinks linked to cancer finds studyMeanwhile, they showed that in this altered environment, MDSCs and the IL-10 they produce were at higher levels and so were the two genes that ultimately silence IRF8. They found the same shifts in human colon cancer.Liu says it’s likely the high levels and timing that transform the role of IL-10 from suppressor of inflammation to suppressor of IRF8.Colorectal cancer is among the top five common cancers and causes of cancer death in men and women in the United States, according to the Centers for Disease Control and Prevention.Interleukin 10, or IL-10, is a cytokine, or signal that influences the behavior of nearby cells. It’s known to suppress chronic inflammation, including inflammation-driven colitis and colorectal cancer. It has even known to suppress other cells cancer might commandeer like regulatory T cells, or Tregs, which can suppress an antitumor response.IRF8 is a transcription factor, which means it helps regulate the activity of genes, and it plays an important role in the differentiation of red blood cells. It’s normally expressed by the epithelial cells that line the colon as a layer of protection against the food and drink we put in our mouths.MDSCs, are at low levels in most healthy people, and are adept at helping protect us from invaders, producing immune cells like macrophages, as well as IL-10. Like inflammation, MDSCs should be on the scene and active just until the problem is eliminated. But when chronically stimulated, like in chronic inflammation and cancer, they work instead to suppress the immune system.Colitis is when the colon’s lining becomes chronically inflamed and its important barrier function gets compromised by the increased number of immune cells that have moved in, likely in response to the immune system inexplicably recognizing common things like food and commensal bacteria in the gut as invaders.Colitis affects males and females alike, often surfaces in the 30s, and can run in families. Symptoms of colitis include loose and more urgent bowel movements, diarrhea, abdominal pain and blood in the stool, according to the Crohn’s & Colitis Foundation. Patients may have a loss of appetite, weight and energy. Source:https://www.augusta.edu/mcg/last_img read more

Researchers identify four hallmarks of cancer metastasis

first_img Motility and invasion Modulation of the microenvironment Plasticity Ability to colonize Defining the hallmarks of metastasis has been complicated by both heterogeneity among tumor cells, and the myriad interactions with other molecules and cells throughout the process, according to the authors.Hurst and Welch say they hope that refining definitions and bringing together diverse data will identify vulnerabilities that metastasis researchers can exploit in the quest to treat cancer metastasis.Hurst, who also serves as an associate scientist at the O’Neal Comprehensive Cancer Center at UAB, explains why metastasis is hard to understand.”Metastasis is a highly complex pathological process,” Hurst said. “Increased specificity in defining the underlying principles is important to better understand and interpret the literature to move forward in the development of therapeutic interventions.” Reviewed by Kate Anderton, B.Sc. (Editor)May 3 2019Researchers at the University of Alabama at Birmingham and the University of Kansas Cancer Center have identified four hallmarks of cancer metastasis — when cancer has spread to different parts of the body from where it started. Metastasis is believed to be the cause of up to 90 percent of cancer deaths.Douglas Hurst, Ph.D., assistant professor in the UAB Department of Pathology, and Danny Welch, Ph.D., associate director of Education at the KUCC, conducted a literature review of more than 10,000 publications on metastasis, and published their findings in Cancer Research, from the American Association for Cancer Research.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerStudy reveals link between inflammatory diet and colorectal cancer riskSugary drinks linked to cancer finds studyMetastasis can be very difficult to treat. Virtually any cancer type can form metastatic tumors. The most common sites for cancers to metastasize include the brain, bones, lungs and liver. Other areas include the adrenal gland, lymph nodes, skin and other organs.By defining the unique properties of metastatic cancer cells, Hurst says, he hopes to provide a conceptual framework to accelerate the discovery of treatment strategies.”Our attempts to identify the underlying first principles of the metastatic process hopefully provide a means for simplifying the processes that are essential for all metastases to develop,” the authors said in the review.Hurst and Welch identified four hallmarks of metastasis:center_img Source:https://www.uab.edu/news/research/item/10453-new-review-identifies-four-hallmarks-of-cancer-metastasislast_img read more

Iran bans government bodies from using foreign message apps

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Russian court blocks Telegram messaging app in privacy row Explore further Citation: Iran bans government bodies from using foreign message apps (2018, April 18) retrieved 18 July 2019 from https://phys.org/news/2018-04-iran-bodies-foreign-message-apps.html Iran’s presidency has banned all government bodies from using foreign-based messaging apps to communicate with citizens, state media reported Wednesday, after economic protests organized through such apps shook the country earlier this year. Chief among those apps is Telegram, used by over 40 million Iranians for everything from benign conversations to commerce and political campaigning. Iranians using Telegram, which describes itself as an encrypted message service, helped spread the word about the protests in December and January.Telegram channels run on behalf of Iran’s Supreme Leader, Ayatollah Ali Khamenei, and Vice President Eshaq Jahangiri were already shut down Wednesday.A report on the website of Iran’s state television broadcaster said the ban affected all public institutions. It was not clear if the ban applied to civil servants outside of work hours. The report did not elaborate on penalties for violating the ban.Last month, officials said Iran would block Telegram for reasons of national security in response to the protests, which saw 25 people killed and nearly 5,000 reportedly arrested.Authorities temporarily shut down Telegram during the protests, though many continued to access it through proxies and virtual private networks.The move against Telegram suggests Iran may try to introduce its own government-approved, or “halal,” version of the messaging app, something long demanded by hard-liners. Already, Iran heavily restricts internet access and blocks social media websites like Facebook and Twitter.Iran has said foreign messaging apps can get licenses from authorities to operate if they transfer their databases into the country. Privacy experts worry that could more easily expose users’ private communications to government spying.Khamenei, however, has stressed that invading people’s privacy is religiously forbidden.Iran’s move also comes after a Russian court on Friday ordered Telegram to be blocked after the company refused to share its encryption data with authorities.Telegram CEO Pavel Durov responded to the ruling by writing on Twitter: “Privacy is not for sale, and human rights should not be compromised out of fear or greed.” A man uses his cell phone while walking on a sidewalk in downtown Tehran, Iran, Wednesday, April 18, 2018. Iranian state TV reported Wednesday that government bodies have been barred from using foreign messaging apps. State TV said the ban was imposed by the Presidential Office on all public institutions. It was not clear if the ban applied to civil servants outside of work hours. (AP Photo/Vahid Salemi) © 2018 The Associated Press. All rights reserved. read more

True blue picks A snapshot of Australias favourite porn

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. This article is republished from The Conversation under a Creative Commons license. Read the original article. Explore further Lesbian was the most popular category of porn among Australians, ranking first across all state capitals. MILF ranked second for all metropolitan regions except Canberra, where hentai came in second place, pushing MILF into third spot. Teen(18+) porn proved to be more popular in Adelaide (equal second) and Brisbane (equal third) whereas threesome porn ranked third in Melbourne and Sydney. Anal took out third place in Perth.Japanese-categorised porn made the top 10 in just three cities—Canberra (equal sixth); Melbourne (ninth) and Sydney (seventh). This was also true for Asian porn. Transgender porn, made it into the top 10 in only two cities—Adelaide (ninth) and Brisbane (tenth) (and 11th in Perth). Given the increased prominence of transgender porn at the 2018 AVN Adult Entertainment Expo, high-profile Australian performer Angela White recently shooting her first transgender scene with Chanel Santini, plus wider media and public debates on trans issues, more people, including heterosexual male porn viewers, will likely be watching transgender porn in the next year or two.What about gay porn?Pornhub also has a separate site for gay porn. While this type of porn may be popular with gay men, it is also watched by women. Pornhub offers about 40 different categories of gay porn on its website. In 2017, the top 10 categories across all Australian cities were: straight guys (in which gay men have sex with “straight” men); bareback (sex without using condoms); daddy (the gay equivalent of “MILF” porn); twink (the equivalent of the category “Teen 18+”); big dick; rough sex; group; public; creampie; and Asian.Canberra is the only city to feature muscle, hunk, and fetish porn in their gay porn top 10. Similarly, black porn only makes the top 10 in Adelaide (seventh) and Brisbane (tenth). Brisbane and Perth are the only cities to feature public porn (ninth).From computers to phonesIt should come as no real surprise that desktop computers are no longer the primary means of accessing porn on the net. Smart phones account for the majority of unique traffic to Pornhub from Australia. Brisbane leads the way with 62.4 percent of porn traffic coming from phones. Nevertheless, people are still watching on computers, particularly in Canberra—the epicentre of federal politics and bureaucracy—where 38.4 percent of Pornhub traffic came from desktops. Tablets account for a small share of traffic, highest in Hobart and Darwin (both at 14.6 percent). With the 5G mobile phone system just over the horizon, and increasingly cost-effective and larger data packages offered by mobile phone companies, smart phones will undoubtedly increase their dominance in how we access online pornography into the future.In overall terms, our mainstream and gay porn category preferences are fairly stable, although there are some notable inter-city variations.As porn scholar Shira Tarrant notes in her book, The Pornography Industry, “pornography has been around for as long as visual images and the written word have existed.” Given the fact that the past is arguably the best predictor of the future, our curiosity in and consumption of pornography is unlikely to disappear any time soon. Provided by The Conversation Despite the nation’s small size, Australians are the 8th biggest viewers of Pornhub. Credit: Shutterstock.comcenter_img Pornhub, one of the world’s largest online porn sites, provides us with a department store-sized window into our online viewing habits of “mainstream porn.”In 2017 Pornhub had 28.5 billion visits, up from 23 billion (24 percent) in 2016. According to internet analytics firm, Alexa, Pornhub is the 27th most popular website in the world. It ranked 18th within Australia (and 14th in the US, 15th in Canada, and 16th in the UK.)Australians made the eighth highest number of visits to the website—the same position it held in 2016. Given the comparatively small population of Australia, its inclusion in the “top 10” suggests that Australians are, at the very least, curious about porn. Here’s a snapshot of the geographies of online pornography down under.Whereas two-thirds (67.3 percent) of Australia’s population in 2017 lived within the various state and territory capital city regions, these same areas accounted for about 90 percent of the unique pageviews to the multitude of porn category pages on Pornhub’s website. Melbourne and Sydney, which account for 40.6 percent of the population, made more than half of all visits to the site.The significant over-representation of porn consumption from metropolitan Australia may also be explained, in large part, by better telecommunications infrastructure and faster internet download speeds compared to regional and rural Australia.Australia’s top 10Eight categories of porn were found in the top 10 most viewed categories across all Australia’s capital cities. There were: anal, big tits, hentai (a Japanese-influenced form of porn), lesbian, mature (“older women,” often 40-60+ years old), MILF (“glamourous older women,” often 30-50 years old), teen (18+), and threesome. (This article contains explicit terms which some readers and workplaces may find offensive.) Citation: True blue picks: A snapshot of Australia’s favourite porn (2018, October 18) retrieved 17 July 2019 from https://phys.org/news/2018-10-true-blue-snapshot-australia-favourite.html Research finds a majority endorsing revenge pornlast_img read more

Costa Rica bets on ending fossil fuel use by 2050

first_img“We need incentives so people feel motivated to leave the car behind and use a bicycle, which is a more powerful decarbonization measure than changing a fuel car for an electric one,” he said.And Dobles admits the plan won’t alleviate congestion.”The challenges of mobility and displacement will remain. It’s not because we’ll have better technology and more intelligent systems that we’ll stop having mobility problems,” she said.Figueres says all countries need to decarbonize their economies in the face of climate change, but in that regard, Costa Rica does at least has an advantage.Amongst wind, hydro, solar and geothermal energy, the tiny Central American country of five million people is already only 1.5 percent off achieving total self-sufficiency in renewable energy. Explore further That could soon become the norm in Costa Rica, where the government launched a decarbonization plan in February to rid the country of fossil fuels by 2050.”It’s totally realistic and necessary,” said Orlich, a father of two who lives in a mountainous zone east of the capital San Jose.A businessman in the solar panel sector and president of the Association of Electric Mobility—which promotes electric-powered transport—what excites him the most about the government’s plan is the focus on public transport. The aim is to have 70 percent of public transport powered by electricity in 2035—and the whole fleet by 2050.That is an achievable goal according to diplomat Cristiana Figueres, who in 2015 participated in talks to secure the Paris climate accord on limiting global warming.”The government prudently set the 2050 date because that’s what the Paris Agreement demands but I’m confident we’ll manage it before then,” Figueres told AFP.”Once we’ve implemented the process of electrifying transport and relaunched a more efficient agriculture and livestock sector, we shall see an exponential effect on technological change” that will accelerate decarbonization, she added. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. First Lady Claudia Dobles says the decarbonization plan will completely redraw Costa Rica’s urban and rural landscapes Eric Orlich and his wife Gioconda Rojas own two electric vehicles, which they charge at home in the garage thanks to solar panels on their roof. Paris orders 800 new electric buses to fight smog Costa Rican Erick Orlich (R) and his wife Gioconda Rojas (L) run two electric cars powered by solar panels installed on the roof of their house Activist David Gomez says Costa Rica’s decarbonization plan should focus on shifting people out of their cars and onto bicycles Costa Rica aims to do away with fossil fuel powered transport by 2050 The aim is for people to be able to easily access the bus or train by foot or bicycle and connect to the entire public transport system—ending the reign of the car, largely responsible for the capital’s pollution and congestion problems.No congestion solutionThe plan has its critics, though, such as analyst Juan Carlos Hidalgo, from the Washington-based Cato Institute, who says it fails to consider the costs.He said the plan doesn’t take into account the “principle of cost-benefit” but only the “zero emissions goal.””It’s a goal without economic foundations,” he told AFP.For his part, bicycle use activist David Gomez says the plan lacks ambition when it comes to non-motorized transport and won’t solve San Jose’s traffic problems. ‘Car no longer king’Leftist President Carlos Alvarado’s plan is set to extend beyond public transport to incorporate industry, agriculture and livestock, as well as a reforestation program aimed at increasing woodland from 50 to 60 percent of the country.Further elements include modernizing waste management and a green tax reform to replace the loss of fuel tax revenues.”This is a change in our social dynamic and our economy,” first lady Claudia Dobles, an architect responsible for the urban regeneration program, told AFP.”By 2050 our urban and rural landscape is going to look very different, with nicer towns… where the car will no longer be king.” Citation: Costa Rica bets on ending fossil fuel use by 2050 (2019, April 20) retrieved 17 July 2019 from https://phys.org/news/2019-04-costa-rica-fossil-fuel.html © 2019 AFP With regard to transport, there are two key components: an electric train serving the San Jose metropolitan area—the most densely populated in the country—and modernization of the bus network.last_img read more

Handlers Thought This Owl Was Male for 23 Years —Then He Laid

first_img Happy Feet: A Gallery of Pudgy Penguins Kaln inspects his egg. Credit: The Barn Owl Centre An eagle owl named Kaln lived for 23 years at a sanctuary in Gloucester, England. For that whole length of time, its handlers thought it was a male. Then, according to Vincent Jones, founder and trustee of the sanctuary, it laid an egg. The egg wasn’t fertilized, Jones told Live Science, so Kaln won’t get to mother a chick. But still, it was a big surprise to all of Kaln’s handlers. “I think he was just as shocked as we were,” Jones said. [Photos: Salmon-Eating Owls Revealed in Stunning Images]Advertisement Sexing owls is tricky, because males and females outwardly have more or less identical bodies, according to a study published Jan. 24, 2008, in the Journal of Heredity. Unlike mammals and other creatures, there’s no obvious difference even between their genitals. Pretty Bird: Images of a Clever Parrot Originally published on Live Science.center_img Plus, Jones said, his sanctuary has no interest in the biological sexes of the birds it takes in. Most of them are rescued from lives as pets or captive working birds, he said. And the sanctuary has no interest in breeding captive owls, only rehabilitating them. “We have 46 birds,” Jones said. “If they have the behavior of a male, we say they’re male. If they have the behavior of a female, we say they’re female.” Typically, according to the National Aviary, Eurasian eagle owl females lay up to six eggs across a month-long period in late winter. [Whooo Knew? 10 Superb Facts About Owls] Kaln never did that though in his 23 years at the sanctuary, Jones said. “He’s always shown signs of being a male,” Jones added. Many of the male birds in the sanctuary “imprint” on their human handlers and treat them as mates, he said. And during breeding season, “Kaln always wants to bonk everything,” he said. Even genetic tests don’t always show a clear distinction between male-sexed owls from female-sexed owls in many species, according to that 2008 paper. Female-sex birds have Z and W chromosomes, while male-sex birds have two Z chromosomes. But those chromosomes can be similar enough that they’re difficult to distinguish. The authors of that paper specifically tried to distinguish the genes of male and female Eurasian eagle owls and failed. The egg hasn’t changed how the sanctuary views Kaln, Jones said. “It’s no different than people. There’s no difference between male and female. We’re all individuals,” he said. “Kaln is an individual. He’s a very special individual. Now we say he’s a tomboy.” The larger concern is that around the same time the bird laid its egg, it began acting “depressed” and displaying some health issues that turned out to be unrelated. Today (June 27), however, Jones said that Kaln has seemed more active and upbeat. “And that’s what really matters isn’t it? The health of the owl,” Jones said. Penguin Selfie Offers Bird’s Eye ViewCurious Emperor penguins have been captured in Antarctica getting up close and personal on film. The vision was filmed at the Auster Rookery near Australia’s Mawson research stationAustralian Antarctic expeditioner, Eddie Gault, left the camera on the ice when visiting the rookery, and it didn’t take long for the naturally curious birds to seize the opportunity for a selfie.Credit: Eddie Gault/Australian Antarctic DivisionVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65809-male-seeming-owl-lays-egg.html?jwsource=cl已复制直播00:0000:3700:37  Whooo’s in There? Amazing Images of Owlslast_img read more

Heres What It Really Means That Iran Enriched Uranium to 45

first_img The Biggest Unsolved Mysteries in Physics 5 Weird Things You Didn’t Know About Chernobyl What’s That? Your Physics Questions Answered Iran claims it has enriched uranium to 4.5%, breaking the limit of 3.67% set during the 2015 nuclear deal. The move was a response to the U.S. violating the terms of the deal under President Donald Trump’s administration. But what does the enrichment news mean? To a certain extent, this is a question with a simple, chemical answer. As the U.S. Nuclear Regulatory Commission explains on its website, uranium comes in a few different forms (or “isotopes”). All of them have the same number of protons (92) but a different number of neutrons. By far, the most common such isotope in nature is uranium-238, which has 146 neutrons. On Earth, this isotope makes up 99.3% of any sample of naturally occurring uranium. But for nuclear reactors (or bombs), that flavor isn’t very useful. Dense clusters of uranium-238 don’t tend to start nuclear chain reactions. The second most common isotope, however, uranium-235 (making up just about 0.7% of any sample of natural uranium and containing 143 neutrons), does tend to start nuclear chain reactions. In these reactions, the nuclei of the uranium atoms split into smaller nuclei and release neutrons. Those neutrons then cause other nuclei to split, releasing more neutrons for a self-sustaining “chain” reaction that emits enormous amounts of energy. [Top 10 Ways to Destroy Earth] Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65898-iran-uranium-enrichment.html?jwsource=cl已复制直播00:0000:3500:35  Enriching uranium is the process of sorting uranium-238 atoms out of a uranium sample such that the sample includes a higher proportion of uranium-235. Uranium enriched to 3.67% is 3.67% uranium-235. Uranium enriched to 4.5% is 4.5% uranium-235. And so on.  So does Iran’s breaking of its enrichment threshold mean that the country is now significantly closer to having a bomb?  Not really. As the Associated Press reported, 4.5% is enriched enough for Iran to power its peaceful, already-active Bushehr nuclear reactor. But that level falls far short of the standard 90% threshold for “weapons-grade” uranium. And enriching uranium to 90% is an enormous technical challenge. It requires building and operating very advanced centrifuges. If you’ve followed news of international attempts to sabotage the Iranian nuclear effort, you know that the most successful effort — a computer virus called Stuxnet — attacked Iranian centrifuges. Centrifuges are common enough pieces of laboratory equipment. They spin samples of material around so as to generate centrifugal force. Under that intense force, heavier and lighter materials tend to separate. However, a common laboratory centrifuge is nowhere near powerful enough to separate uranium-235 from uranium-238. The two isotopes are nearly, but not quite, identical in mass. And a sample of uranium contains very little uranium-235. As Live Science previously reported, a country seeking to enrich uranium must first transform a uranium sample into a gas. Then, that gas must be whipped up to intense speeds in powerful industrial centrifuges to cause the two isotopes to separate, before the uranium atoms get extracted from the gas once again. To extract the 137 lbs. (62 kilograms) of uranium-235 necessary to build the bomb dubbed “Little Boy” that was dropped on Hiroshima, Japan, the United States in 1945 expended a full 10% of its national energy supply, according to “The Making of the Atomic Bomb” (Simon & Schuster, 1995). The original uranium sample weighed 4 tons (3,600 kilograms). And 20,000 people helped build the refining facility that made the bomb, a facility that required 12,000 people to operate. It’s not infeasible that Iran could enrich a significant stockpile of weapons-grade uranium. But the 4.5% mark doesn’t represent a significant step in that direction, except in symbolic terms. Iran has also threatened to enrich uranium to 20%, which is closer but still not weapons grade. The question now is whether the breakdown of the nuclear deal, precipitated by the U.S., continues to escalate tensions. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 minute and see why everyone is addictedVikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoFinance DailySeniors With No Life Insurance May Get Up To $250,000 If They Do This…Finance DailyUndoAncestryThe Story Behind Your Last Name Will Surprise YouAncestryUndoFinance101Oprah’s Mansion Costs $90 Million, And This Is What It Looks LikeFinance101Undolast_img read more

Feeding Frenzy of 11 Sharks Ends in Surprising Twist … And a

first_img This swarm of small sharks, known as dogfish, are chowing down on a swordfish. Credit: NOAA Office of Ocean Exploration and Research, Windows to the Deep 2019 Images: Sharks & Whales from Above Though surprising, this isn’t the first time a fish has been caught on camera swallowing a shark. Last year, people fishing off the coast of Florida caught footage of a 500-lb. (227 kg) goliath grouper darting up to the water’s surface and nabbing a 4-foot-long (1.2 m) shark, Fox News reported at the time. One shark expert said this behavior is run-of-the-mill, “fish-eat-fish” ocean life. “It might be unusual to see it, but it’s not entirely unusual [for it to happen], no,” Daniel Abel, a marine biologist at Coastal Carolina University, told Live Science. “A big grouper is going to eat anything smaller than itself.” The law of the ocean food chain is a brutal one, Abel said: Anything smaller than yourself is fair game for predators like sharks and groupers. Large groupers are known predators of sharks like dogfish, Abel said. And aside from humans, sharks are their own greatest predators, he added. The unlucky dogfish caught on camera didn’t fall victim to a fellow shark, but it did just happen to be smaller than the hungry grouper watching it — and too busy chowing down to notice. These Sharks Were Too Busy to Notice a Bigger Predator Watching ThemThe unexpected twist at the end of this feeding frenzy delighted scientists.Credit: NOAA Office of Ocean Exploration and Research, Windows to the Deep 2019Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65926-shark-feeding-frenzy-surprise.html?jwsource=cl已复制自动 270p270p180p正在加载广告直播00:0002:2802:28Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 Catching a glimpse of an underwater feeding frenzy involving 11 sharks was enough to startle and exhilarate a group of scientists off the coast of South Carolina last month. But the researchers lost their minds when a sneaky guest, a wreckfish, swam directly in front of their camera with one of the sharks wriggling around in its mouth. The fish had swallowed a shark whole, as the busy predators darted about to grab morsels from the 250-lb. (110 kilograms) carcass of a swordfish.Advertisement “Oh my god — I’m going to remember this my whole life,” one of the researchers says in footage of the feeding frenzy. [In Photos: Great White Sharks Attack] A remotely operated vehicle called the Deep Discoverer captured the video. The scientists operating the vehicle were conducting research for the National Oceanic and Atmospheric Administration (NOAA) aboard the ship Okeanos Explorer. This was the Deep Discoverer’s seventh dive on an expedition called Windows to the Deep. Things didn’t end well for one of the sharks. Credit: NOAA Office of Ocean Exploration and Research, Windows to the Deep 2019 Photos: Orcas Are Chowing Down on Great-White-Shark Organs In Photos: Great White Shark Washes Up on Santa Cruz Beach The scientists were operating the Deep Discoverer 1,476 feet (450 meters) below the surface of the Atlantic Ocean, searching for a World War II shipwreck. They directed the rover up a small incline, expecting to find the boat but instead discovered the swarm of small sharks, called dogfish. The predators had likely sensed this swordfish “food fall” from a long distance and had traveled for the feast, Peter J. Auster of Mystic Aquarium and the University of Connecticut, wrote in the team’s mission log. When the wreckfish, a type of grouper, meandered in front of the camera with a shark tail protruding from its mouth, the scientists came to a clear conclusion: The guest had been watching the feeding frenzy the entire time, stealthily hiding behind the rover itself. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndohear.comThese German hearing aids are going viralhear.comUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoLivestlyThe List Of Dog Breeds To Avoid At All CostsLivestlyUndolast_img read more

PM unveils Ayushman Bharat 50 cr to get health cover of ₹5

first_imgSeptember 23, 2018 COMMENT The world’s largest government-funded healthcare programme, the Pradhan Mantri Jan Arogya Yojana (PMJAY), or Ayushman Bharat, was launched by Prime Minister Narendra Modi in Ranchi on Sunday. Over 10 crore families — both urban and rural poor — will be provided an annual health cover of ₹5 lakh each under the PMJAY.“Some call it Modicare, some call it a scheme for the poor. It is definitely a scheme to serve the poor,” Modi said.He said the scheme would benefit over 50 crore people: the poor, deprived rural families, and identified occupational categories of urban workers’ families. This would imply 8.03 crore households in the countryside, and 2.33 crore families in the urban areas, as per data from the latest Socio-Economic Caste Census.However, the Centre will fund only 60 per cent of PMJAY and States will have to shoulder the remainder of the expense.Modi said the PMJAY provided comprehensive health insurance, covering 1,300 illnesses, including serious ones such as cancer and diseases of the heart. Private hospitals would also be part of the scheme. Health cover for secondary and tertiary care hospitalisation would be made available through a network of empanelled health-care providers.The Prime Minister claimed the insured amount of ₹5 lakh would cover all investigations, medicine, pre-hospitalisation expenses, etc. It would also cover pre-existing illnesses. People can learn more about the scheme by dialling 14555, or through their Common Service Centre. There will be no cap on the family size and age under PMJAY. Modi said the first part of Ayushman Bharat — health and wellness centres — was launched on BR Ambedkar’s birth anniversary (April 14) and the second, the health assurance scheme, is being launched two days before the birthday of Jan Sangh ideologue Deendayal Upadhyay (September 25).The Prime Minister said those people who were permanent residents of States that had subscribed to PMJAY could enjoy its benefits in any other State that had also signed up for the scheme. He also spoke of the 10 health and wellness centres inaugurated on Sunday. The number of such centres has reached 2,300, and the aim is to increase this to 1.5 lakh in four years.India Inc upbeatResponding to the launch of Ayushman Bharat, Prathap Reddy, Founder and Chairman, Apollo Hospitals, said: “ I feel as happy as I did when we launched the first universal insurance scheme in my village in the year 1999.” However, he voiced concerns over “potential fraud” and the “pricing and reimbursements” to the private sector, which, he said, “must remain paramount”. Anuj Gulati, Managing Director & CEO, Religare Health Insurance, said: “Ayushman Bharat will bring in the much-needed revolutionary change to healthcare in India.” Shreeraj Deshpande, Head, Health Insurance, Future Generali India Insurance, said the success of the ambitious Ayushman Bharat scheme would depend on its effective implementation. “This scheme would definitely increase awareness among the population and help set in some standards of care especially in rural areas,” he said.Ashish Mehrotra, MD & CEO, Max Bupa Health Insurance said: “We truly believe that the scheme will have a positive impact on the current healthcare ecosystem, in lieu of the rising medical inflation, with people spending about 60-65% on out-of-pocket expenses.” RELATED Published on Prime Minister Narendra Modi hands over the replica of a health card to a beneficiary of the PMJAY, in Ranchi on Sunday. Union Health Minister JP Nadda, Jharkhand Governor Droupadi Murmu and State Chief Minister Raghubar Das are also seen MANOB CHOWDHARY Ayushman Bharat credit positive for insurers: Moody’scenter_img SHARE SHARE EMAIL SHARE health Targeting poor, world’s largest health scheme kicks off in 31 provinces COMMENTSlast_img read more

HP Kerala TN top Niti Aayog index on development goals

first_imgSHARE SHARE EMAIL Chandigarh (UT) United Nations Government think tank NITI Aayog on Friday came out with a baseline index of Indian states’ performance on various UN Sustainable Development Goals (SDGs), which found the states of Himachal Pradesh, Kerala and Tamil Nadu and the Union Territories of Chandigarh and Pondicherry, are among the front-runners.SDGs, adopted by 193 countries at the UN General Assembly Summit in September 2015, are a set of 17 goals across social, economic and environmental spheres that would transform the world into a better place by 2030. This agenda for sustainable development based on SDGs, came into effect in January 2016.  While Kerala’s top rank is attributed to its superior performance in providing good health, reducing hunger, achieving gender equality and providing quality education, Himachal Pradesh has surged to the top backed by its success in providing clean water and sanitation, in reducing inequalities and preserving the mountain ecosystem. Tamil Nadu, on the other hand, did well in reducing poverty and providing affordable and clean energy to people.“It is widely acknowledged that the world cannot achieve the SDGs without India achieving them. The Government’s flagship programmes such as Swachh Bharat Mission, Ujjwala, Gram Jyoti Yojana and others are directed towards addressing these key national priorities, which are inextricably aligned with SDG targets,” said NITI Aayog Vice-Chairman Rajiv Kumar.According to him, the think tank will track the performance of the states, using 62 parameters associated with SDGs. The states would be ranked on the basis of their performance on each of these SDGs, barring four goals such as Climate Action, for which the state-wise break-up of data is not currently available. Some of the prominent SDGs are No Poverty, Zero Hunger, Quality Education, Gender Equality, Clean Water and Sanitation, Good Health and Well-being.The baseline index was created by computing a composite score for each state and UT based on their aggregate performance across 13 of the 17 SDGs. The score indicates the average performance of the state/ UT in achieving the 13 SDGs and their respective targets. The score ranges between 0 and 100. If a state achieves a score of 100, it signifies that the state has achieved the national target set for 2030.The SDG Index Score for Sustainable Development Goals 2030 ranges between 42 and 69 for states and between 57 and and 68 for UTs.“The idea is to create competition among different states so that they work towards improving their performance on each of these scores and bettering their standing,” Kumar said.Addressing the meeting, NITI Aayog CEO, Amitabh Kant, said the SDG index has been created using officially available data and after intense discussions with the states. The index can provide a holistic view on the social, economic and environmental status of the country. It will go a long way in helping analyse and identify best practices and priority areas, giving direction to developmental policies. “The index would strive to capture these changes as and when they happen on a real-time basis,” Kant said.Yuri Afanasiev, UN Resident Coordinator in India, said India could be one of the first countries in the world to create one such bench-marking index, and it was commendable. “Over the last decade, hundreds of millions have been lifted out of poverty in India through targeted schemes across sectors. India has also emerged as a global leader on the international climate action agenda and an enabler of sustainable development for developing countries around the world, Afanasiev said.The states currently at the bottom of the ladder, Uttar Pradesh, Bihar and Assam, have a lot of ground to cover in many spheres, before they catch up with the others in ranking. COMMENT SHARE Himachal Pradesh Himachal surges to the top based on its success in providing clean water and sanitation, reducing inequalities Tamil Nadu December 21, 2018 COMMENTS Pondicherry Published on Keralalast_img read more

Farm loan waiver scheme rolling out smoothly

first_imgSHARE SHARE EMAIL COMMENT Karnataka SHARE COMMENTS farm loanscenter_img Published on “Karnataka has been successfully implementing the farm loan waiver scheme and in a most transparent way,” Chief Minister H D Kumaraswamy said in his budget speech. The Chief Minister said that under the Loan Waiver scheme, ₹5,450 crore has been released so far for about 12 lakh loan accounts of commercial banks. Out of this, crop loan amount of ₹1,027 crore for 2 lakh loan accounts of cooperative banks and ₹843 crore for 1.9 lakh loan accounts of commercial banks has been released. Transparency“Without giving scope for leakage of taxpayers’ money, loan waiver amount is being released directly to the farmer’s loan accounts and the complete process is transparent like an open book,” he claimed.Kumaraswamy said that so far 17 lakh farmers have already submitted self declaration certificates in respect of about 20 lakh farm loan accounts of commercial banks and regional rural banks till date. In the same manner, out of 20 lakh accounts, information of 19 lakh accounts has been obtained from the co-operative banks. Other farmers are being contacted through the Revenue Department. For the commercial banks crop loan waiver scheme announced in July budget 2018, a provision of ₹ 6,500 crore had been made in 2018-19. So far ₹2,850 crore has been released to benefit about 6 lakh farmers. For the co-operative banks crop loan waiver scheme, the entire budget provision of ₹2,600 crore has been released, which will help 5.97 lakh farmers. In 2019-20, a budget provision of ₹6,500 crore for commercial bank crop loans and ₹6,150 crore for cooperative bank crop loans has been made. The cooperative loan waiver process is scheduled to be completed by June 2019. It is expected that the commercial bank loan waiver will also be completed during the financial year 2019-20. Plea to Centre Kumaraswamy said, “We have already represented to the Central government to provide ₹2,434 crore package for kharif crop. The Central government has agreed to give ₹950 crore only. We have again represented to the Central government to provide ₹2,065 crore for the rabi crop and are awaiting their response.” “Our government has made substantial allocations for the welfare of the farmers of the State. We have kept in mind all the activities relating to agriculture from production to the consumer, in order to make agricultural activity a profitable industry,” he added. State Budget February 08, 2019last_img read more

Kasaragod killing Kerala Governor seeks reportKasaragod killing Kerala Governor seeks report

first_imgCOMMENTS February 19, 2019 crime, law and justice state politics Kerala Governor P Sathasivam on Tuesday sought an urgent report from Chief Minister Pinarayi Vijayan on the status of the police probe into the killing of two youth Congress workers at Periya in Kasaragod.Opposition Leader in the State Assembly Ramesh Chennithala had met the Governor to brief him about the issue, a release from the Governor’s office said.Chennithala had informed the governor that the families of the victims were under utmost grief due to their personal loss and delay in arresting culprits.‘Monitoring law and order’Since the post of ADGP North was lying vacant for the last 6-8 months, monitoring of law and order in the district had been affected, the Congress leader had alleged.It was in this context that the Governor sought the report from the Chief Minister, the release added.The Left government is facing the heat over the killings of Kripesh (24) and Sarath Lal (21), the Youth Congress activists, who were waylaid and attacked while returning home after attending a function on Sunday night.The Opposition Congress and the BJP have alleged that the killings were executed with the knowledge and support of the ruling CPI(M) leadership.Chief Minister Pinarayi Vijayan has said the CPI(M) never promoted violence and asserted that the party had no role in the recent killings.The Left party has also demanded a CBI probe.State CPI(M) secretary Kodiyeri Balakrishnan on Tuesday reiterated that his party had no knowledge of the twin killings. SHAREcenter_img Published on COMMENT SHARE SHARE EMAIL Keralalast_img read more

Dzulkefly Internal inquiry set up to probe Orang Asli claims of forced

first_img Tags / Keywords: Nation 11 Jul 2019 Waytha: Govt will probe allegations birth control forced on Orang Asli Dr Dzulkefly Ahmad , Orang Asli , birth control Nation 11 Jul 2019 Health Ministry: Back up allegations of forced birth control with evidence Related News KUALA LUMPUR: The Health Ministry has set up an internal inquiry to investigate the allegations that Orang Asli women were given birth control treatment without their consent, says Dr Dzulkefly Ahmad.center_img The Health Minister said that that the inquiry was set up a couple of days ago and would be led by a family medicine specialist and the panel would include a matron, staff nurses and doctors.”The inquiry will have three terms of reference – to investigate if the allegations are valid or baseless, to identify the weaknesses in family planning programme delivery to the Orang Asli and to propose improved delivery of the family planning programme,” Dzulkefly told the press after launching the World Food Safety Day on Saturday (July 13).On Tuesday (July 9), representatives from five Orang Asli villages submitted a memorandum to the government at the Parliament building here, claiming that birth control injections were administered to women in their communities. Nation 11 Jul 2019 Birth control injections given to protect Orang Asli women from unsafe pregnancies, says Health Minister Related News {{category}} {{time}} {{title}}last_img read more

Duterte mocks iceeating Iceland over UN vote on Philippine war on drugs

first_img {{category}} {{time}} {{title}} World 08 Jul 2019 Executions ‘rampant’ in Philippine drug war, U.N. probe needed – Amnesty report Related News Philippines 11 Jul 2019 Do your homework and read report, Philippines’ Panelo told MANILA (Reuters) – Philippine President Rodrigo Duterte took a swipe at Iceland on Friday for spearheading a U.N. resolution to investigate his bloody war on drugs, saying it was a nation made entirely of ice, with no understanding of his country’s problems.”What is the problem of Iceland? – Ice only. That is your problem. You have too much ice and there is no clear day and night there,” he said in a rambling speech to corrections department officials.”So you can understand why there is no crime, no policeman either, and they just go about eating ice.”They don’t understand the social, economic, political problems of the Philippines.” AdChoices广告The resolution on the Philippines, led by Iceland, was adopted by the U.N. Human Rights Council on Thursday by a vote of 18 countries in favour and 14 against, with 15 abstentions.The exact number of dead in Duterte’s war on drugs is impossible to independently verify. Police say they have killed 6,600 who were armed and fought back during attempts to arrest them, but activists say there may have been as many as 27,000 drug-related killings overall.Human rights groups say there is a pattern of executions, planted evidence and falsified reports, and a state unwilling to investigate widespread allegations of systematic abuses by police during the three-year-old crackdown. The government rejects that as lies.Duterte’s spokesman, Salvador Panelo, said on Friday Iceland had introduced a resolution “based on false information, bogus news”, and relied on narratives of Duterte’s opponents and biased media.He told news channel ANC that Duterte would permit United Nations investigators to conduct a probe in his country “if he finds the purpose legitimate”.Duterte defended his crackdown and said something had to be done because millions of Filipinos were “slaves to a drug called shabu”.”They are inutile,” he added. “If they have no money, they steal, kill. Now if you want to destroy a man or if you want to destroy a family, place one addict in that family. It would be hell for them for all-time.”Referring to frequent criticism that he publicly gave police orders to kill, he said there was nothing wrong with protecting his country.”I am asking the human rights people. Is it wrong to say if you destroy my country I will kill you? Is that a crime for a president mayor or a governor to say that in public?” (Reporting by Neil Jerome Morales and Martin Petty; Editing by Nick Macfie) World 09 Jul 2019 Amal Clooney to join legal team defending Philippine journalist Maria Ressa Related Newslast_img read more